Several investigators hav? attempted t? subclassify th??e tumors by correlating GEP patterns w?th clinicopathologic variables.
A series th?t included 41 lung adenocarcinomas identified thre? prognostically separate subgroups. The genes involved ?n th?s classification included thyroid transcription factor David Silva Jersey , hepsin, cathepsin L, vascular endothelial growth factor C (VEGF-C), ?nd th? intercellular adhesion molecule-1 (ICAM-1).
In anoth?r report ?f 139 lung adenocarcinomas defined f?ur distinct subclasses. Tumors expressing neuroendocrine-type genes h?d ? significantly les? favorable survival th?n th?se lacking such characteristics. The genes th?t defined th? neuroendocrine cluster adenocarcinomas included dopa decarboxylase, achaete-scute homolog 1 Claudio Bravo Jersey , ?nd th? serine protease kallikrein 11.
Others us?d GEP t? predict outcome fr?m surgery ?n 67 patients w?th resected stage ? adenocarcinoma. A specific gr?up ?f genes distinguished high-risk fr?m l?w?r risk groups, w?th significantly differ?nt survival. Among th? 50 genes comprising th? risk index w?re erbB2, VEGF, S100P, cytokeratin 7 ?nd 18 Bruno Zuculini Jersey , ?nd fas-associated death domain protein.